Stalidearm Cosmetic Co., Ltd.

Stalidearm Cosmetic Co., Ltd.
Drug combination therapy is commonly used to treat hyperpigmentation. However, treatment success is often limited due to the insufficient activity of combined drugs. To improve the therapeutic efficacy of drug combination treatment, we synthesized and investigated several conjugates comprising homo- and heterogeneous anti-pigmenting drugs bound to a hyaluronic acid (HA) carrier through distinct biodegradable linkers. These HA-drug conjugates demonstrated a measurable drug release profile in hydrolytic media. Most of the tested conjugates, administered by mesotherapy after UV-light-induced pigmentation in a swine model, presented superior depigmentation over corresponding controls. Among them, the dendron-like conjugate, NH2-TXA-Tris-TXA-(EtCMB)3, that contains only tranexamic acid (TXA), was most effective at depigmenting the swine skin compared to its equimolar mixture of HA and TXA (control). These results emphasize the importance of conjugation depigmenting agents to HA for augmenting the efficacy of treatment and motivate the use of HA as a delivery platform for treatment of various skin disorders.

Trend Frontiers

Release time：2020-06-12
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At present, there are more than 2400 certified production enterprises in Guangdong Province, accounting for more than half of the country's 3800 certified enterprises. The Guangdong Provincial Food and Drug Administration organized an expert team to conduct a step-by-step inspection of the enterprise in accordance with 105 key points of the "Cosmetics Production License Inspection" and other regulatory requirements. Only after passing the strict inspection can a new certificate be issued. The reform of the cosmetics production license system has officially entered the implementation period from the transitional period, marking the entry of a new certification era in China's cosmetics production.
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Two certificates in one, the trend is approaching2020-06-12
Refers to the new "Cosmetics Production License", which replaces the original two certificates of the "National Industrial Product Production License" and the "Cosmetics Production Enterprise Hygiene License" held by cosmetics production enterprises. This new regulation is referred to as the "two certificates in one". According to the document issued by the State Food and Drug Administration on December 15, 2015: Notice of the State Food and Drug Administration on Doing a Good Job in the Production License of Cosmetics [2015] No. 265, a new version of the Cosmetics Production License must be obtained from January 1, 2016 to December 31, 2016. Starting from January 1, 2017, enterprises without a new "Cosmetics Production License" will not be able to continue production.
Trend Frontiers2020-06-12
At present, there are more than 2400 certified production enterprises in Guangdong Province, accounting for more than half of the country's 3800 certified enterprises. The Guangdong Provincial Food and Drug Administration organized an expert team to conduct a step-by-step inspection of the enterprise in accordance with 105 key points of the "Cosmetics Production License Inspection" and other regulatory requirements. Only after passing the strict inspection can a new certificate be issued. The reform of the cosmetics production license system has officially entered the implementation period from the transitional period, marking the entry of a new certification era in China's cosmetics production.
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